Cysmethynil ID:1594
Synonyms: |
CAS NO : 851636-83-4 |
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Molecular Formula: C25H32N2O |
Molecular Weight: 376.53438 |
Purity: 98% |
Solubility: In DMSO |
Storage: -20°C |
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Remarks:Cysmethynil is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with antitumor activity in cancer cells. Cysmethynil treatment results in inhibition of cell growth in an Icmt-dependent fashion, demonstrating mechanism-based activity of the compound. Treatment of cancer cells with cysmethynil results in mislocalization of Ras and impaired epidermal growth factor signaling. In a human colon cancer cell line, cysmethynil treatment blocks anchorage-independent growth, and this effect is reversed by overexpression of Icmt.
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H-NMR,C-NMR,LC-MS,HPLC. |
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